Triphenylphosphine, also known as triphenylphosphine, is an organic compound with the chemical formula C18H15P and CAS Registry number 603-35-0. It is a white crystalline powder with a melting point of 79-81°C, a boiling point of 360.0±11.0°C, and a density of 1.132 g/cm³. It is insoluble in water, slightly soluble in ethanol, and readily soluble in organic solvents such as ether and benzene. It should be stored in a cool, well-ventilated place, away from oxidizers and sources of ignition.
It is mainly used as a polymerization initiator, Wittig reagent, and ligand for metal catalysts (such as Pd(PPh3)4) in organic synthesis. It can also act as a reducing agent to generate triphenylphosphine oxides. In the pharmaceutical field, it is used to prepare chlorpheniramine, and in the pesticide industry, it is used to synthesize organophosphorus intermediates such as trimethyl phosphite. Its safety terms include R22 (harmful if ingested), R43 (sensitizing if in contact with skin), and R53 (long-term hazard to aquatic environments). The acute toxicity LD50 in rats via oral administration is 700 mg/kg, and eye contact in rabbits with 500 mg can cause mild irritation.
